Tylenol with Naproxen: New OTC Pain Pill Cuts Opioid Use by Nearly 40%
Summit, N.J. – – September 11, 2026 -- A new over-the-counter pain reliever combining acetaminophen and naproxen sodium in a single pill has cleared two Phase 3 clinical trials, with data presented this week at the 20th Annual PAINWeek Conference in Las Vegas, running September 8-11, 2026.
TYLENOL with Naproxen pairs 650 mg of acetaminophen with 220 mg of naproxen sodium, a combination the FDA approved in July 2026 as the first and only OTC product of its kind. The formula starts working in under 30 minutes and delivers relief for up to 12 hours, according to Kenvue, the brand's parent company.